It’s scary that prion seems to be the actual human gene sequence broadcast to humans in mad cow disease, and the "prion antibody gene sequence" has long been hidden in it.
This is also a very normal situation. Even in the feudal era, there have been many cannibalism tragedies in human history.
What’s more, cannibalism was very normal in ancient times.
So it’s not surprising that humans have prion antibodies.
According to the data of the follow-up study of AIDS patients in these decades, it can be seen that the life expectancy of patients has increased and the virus has gradually weakened its lethality to ensure that patients will not die.
At present, cocktail therapy in various AIDS treatment schemes can cure the symptoms; However, there is no hope that vaccine research and development will not keep up with the speed of virus mutation because the virus mutates too fast.
In gene editing, the technology of infant congenital epidemic is immature, and it also faces legal and ethical problems.
It is feasible to develop this "trap method" with Shennong Group.
first day of the lunar year
Dr. Li and other doctors came to the hospital early in the morning for an early meeting.
"Four patients didn’t have rejection reaction. I’m going to inject mutated cells today and then trap them the next day."
Another doctor nodded his head. "I agree that the patient has no obvious rejection variation after three rejection tests, and the safety of the cells is not a big problem."
After more than half an hour’s discussion, the problems that may be encountered in each link were identified.
2: 30 p.m.
Dr. Li, Liu Xing and two nurses injected mutated cell solution into four patients, which decreased little by little with the infusion bottle solution.
Liu Xing and others always note the patient’s physical sign data and are ready to deal with emergencies.
Fortunately, the process was thrilling, except for one patient who had some dizziness and slight fever, others did not show any rejection.
After the mutant cells were injected, the cell suspension agent was injected and the antiviral drugs were suspended.
Targeted drugs enter the normal cells of patients with suspended animation, which is also the last hiding place of HIV in the human body and the root cause of AIDS being eliminated all the time.
When the fake death agent enters normal cells, these cells become abnormal as if they were in a dying state.
However, the hidden HIV will soon be abnormally separated from the cell, and these viruses will not be so easy to come out if antiviral drugs are not suspended.
According to animal test data, Dr. Li usually breaks away from normal cells in about 24~32 hours and proliferates rapidly in other cells of human body.
In the waiting process, gold nanorod particles are sent into the mutant cells through targeted drugs.
At the same time, the patient is asked to send a specific interfering drug into normal cells with another targeted drug.
Four hours later, the patient was forced to return HIV to the cells with antiviral drugs. Because the normal cells are in suspended animation, the virus naturally does not choose to add interfering drugs to the dying cells to make the virus feel threatened.
Therefore, these viruses can retreat to mutant cells in addition to being killed by cocktail therapy drugs.
Short-term double cocktail therapy drugs make patients’ bodies appear obvious.
However, Dr. Li and Liu Xing and others know that at this time, we must kill HIV in normal cells with strong drugs and never let go of a fish that escapes from the net, otherwise it will fall short.
Three days later, the patient’s body was destroyed by cocktail therapy and doubled drugs, and he turned pale and entered a dying state.
Liu Xing ran excitedly with a test report. "Dr. Li has good news. The virus content in normal cells of patients has been continuous for 12 hours."
Dr. Li decided "Good! Carry out the final photothermal killing. "
Chapter four hundred and sixty Reaction
Photothermal knife operating room
One patient was taken to the operating table 3.
Five doctors and five nurses are waiting for the three-dimensional human body layer formed by the comprehensive human body scanning system, which is full of dense red spots.
These red spots are the resonance reflection of gold nanorod particles.
The attending physician should clean up the arms and legs first.
When that near-infrared light wave with that specific frequency is excite from the laser to irradiate the arm of the patient
You can see that the red spots on the arms in the comprehensive human body scanning system are disappearing rapidly.
This is because the gold nanorods quickly heat up after absorbing the heat of near infrared light, and then the gold nanorods reach the critical point and instantly burn the mutant cells.
And the HIV in the hidden mutant cells was also destroyed by high heat. After all, the instantaneous temperature was more than 300 degrees Celsius, which made the organic structure of fen quickly destroyed.
This precise and rude physical destruction did not give mutant cells and HIV a chance, and it was a quick and painful killer.
After an hour and a half, it can be seen from the patient’s body scanning that the gold nanorods have disappeared and completely become gold.
This also announced the successful conclusion of the operation.
Then the second patient was sent to the photothermal knife operating room.
Outside the operating room, Dr. Li and Liu Xing also discussed the arrangement.
Although the animal experiment was very successful, there was no relapse after the chimpanzee’s HIV was cleared, and so did his animal tests.
After all, the physical killing by photothermal knife is to directly burn the organic matter, and the acceleration of the structure is very fast, so the root does not produce tolerance for the virus.
HIV is sensitive to heat and tolerant to low temperature, and the HIV activity will be reduced to 9-99% in a few hours in a high temperature and dry environment.
But room temperature (22~27℃) liquid environment can live for 15 days; 3 minutes at 56℃ can make HIV lose infectivity to human cells in vitro, but it can’t completely inactivate the virus in serum; Infectious virus can not be detected in serum after 3 hours at 6 degrees Celsius or 3 minutes at 6 degrees Celsius.
At present, the inactivation method recommended by WHO is 1 degree Celsius for 2 minutes.
The instantaneous high temperature produced by photothermal knife reaches more than 300 degrees Celsius, and viruses and cells will be instantly burned and deteriorated, which is commonly known as ripening.
Soon these degenerated cells and virus remains will be swallowed and absorbed by normal cells around them and become human nutrients.
After more than six hours, when the last patient was sent out of the operating room, the clinical test finally came to an end, and then the patient’s recovery was observed to see if there were any signs of relapse.
If there is no relapse, it means that HIV has been removed from the patient.
Liu Xing is responsible for observing the patient’s condition.
After gradually reducing the amount of antiviral drugs, the patients’ somatic cells were analyzed by face test two weeks after stopping the drugs.